The Geisinger Medical Laboratories Anatomic Pathology Staff
Dr. George Lin
GEORGE LIN, MD, PhDAnatomic Pathology, Dermatopathology
Education:
Dr. Lin is a graduate of Harvard University and holds an MD and PhD in Cellular and Molecular Biology and Virology from the University of Pennsylvania School of Medicine. He completed an Anatomic Pathology Residency at Brigham and Women's Hospital and a fellowship in Dermatopathology at Harvard Medical School.
Certifications:
Dr. Lin is board-certified in Anatomic Pathology.
Professional Affiliations:
Massachusetts Medical Society
Chinese Biopharmaceutical Association
Research Interests:
Dermatopathology, hair growth and regulation, HIV pathophysiology, and vaccine development.
Publications in Peer-Reviewed Journals:
Lin, G., A. Bertolotti-Ciarlet, B.S. Haggarty, J. Romano, K.M. Nolan, G.J. Leslie, A.P. Jordan C.C. Huang, P.D. Kwong, R.W. Doms, and J.A. Hoxie. (2007). “Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists.” Journal of Virology. 81, 9956-9966.
Lin, G., and P.L. Nara. (2007). “Designing Immunogens to Elicit Broadly Neutralizing Antibodies to the HIV-1 Envelope Glycoprotein.” Current HIV Research. 5, 514-541.
Nara, P.L., D. Nara, R. Chaudhuri, G. Lin, and G. Tobin. (2008). “Perspectives on Advancing Preventative Medicine through Vaccinology at the Comparative Veterinary, Human and Conservation Medicine Interface: Not Missing the Opportunities.” Vaccine. 26, 6200--6211.
Garrity, R.R., G. Lin, N. Dunlop, P. Nara, G. Rimmelzwaan, J. DeJong, W. Keulen, J. Goudsmit, A. Minassian, S. Conley, W.-P. Tsai, and J. Moore. (1994). "Site-directed Mutations Introduced into the V3 Domain of HIV-1 gp120 Results in an Augmented Humoral Response to Other Epitopes." Vaccines 94, Cold Spring Harbor Press: New York, 261-267.
Garrity, R.R., G. Rimmelzwaan, A. Minassian, W.-P. Tsai, G. Lin, J.-J. de Jong, J. Goudsmit, and P.L. Nara. (1997). "Refocusing Neutralizing Antibody Response by Targeted Dampening of an Immunodominant Epitope." Journal of Immunology. 159, 279-289.
Garrity, R.R., P.L. Nara, G. Lin, and S. Johnson. (1997). "Genetic Vaccination with Naked HIV-1 RNA Results in Low-titer Anti-gp120 Response." Vaccines 97, Cold Spring Harbor Press: New York, 151-156.
Lin, G., B. Lee, B. Haggarty, R.W. Doms, and J.A. Hoxie. (2001). “CD4-Independent Use of Rhesus CCR5 by Human Immunodeficiency Virus Type 2 Implicates an Electrostatic Interaction Between the CCR5 N Terminus and the gp120 C4 Domain.” Journal of Virology. 75, 10766-10778. T
Turville, S.G., P.U. Cameron, A. Handley, G. Lin, S. Pöhlmann, R.W. Doms, and A.L. Cunningham. (2002). “Diversity of Receptors Binding HIV on Dendritic Cell Subsets.” Nature Immunology. 3, 975-983.
Lin, G., F. Baribaud, J. Romano, R.W. Doms, and J.A. Hoxie. (2003). “Identification of gp120 Binding Sites on CXCR4 by Using CD4-Independent Human Immunodeficiency Virus Type 2 Env Proteins.” Journal of Virology. 77, 931-942.
Lin, G., G. Simmons, S. Pöhlmann, F. Baribaud, H. Ni, G.J. Leslie, B.S. Haggarty, P. Bates, D. Weissman, J.A. Hoxie, and R.W. Doms. (2003). “Differential N-Linked Glycosylation of Human Immunodeficiency Virus and Ebola Virus Envelope Glycoproteins Modulates Interactions with DC-SIGN and DC-SIGNR.” Journal of Virology. 77, 1337-1346.
Pöhlmann, S., J. Zhang, F. Baribaud, Z. Chen, G.J. Leslie, G. Lin, A. Granelli-Piperno, R.W. Doms, C.M. Rice, and J. McKeating. (2003). “Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR.” Journal of Virology. 77, 4070-4080.
Lin, G. and J.A. Hoxie. (2003). “Novel Tyrosine Sulfated Human Antibodies that Mimic HIV-1 Chemokine Receptor CCR5.” Cell. 114, 147-148.
Lin, G., S.L. Murphy, G.N. Gaulton, and J.A. Hoxie. (2005). “Modification of a Viral Envelope Glycoprotein Cell-Cell Fusion Assay by Utilizing Plasmid Encoded Bacteriophage RNA Polymerase.” Journal of Virological Methods. 128, 135-142.
Nara, P.L. and G. Lin. (2005). “HIV-1: The Confounding Variables of Virus Neutralization.” Current Drug Targets – Infectious Disorders. 5, 157-170.
Tobin, G.J., J.D. Trujillo, R.V. Bushnell, G. Lin, A.R. Chaudhuri, J. Long, and P.L. Nara. (2008). “ Deceptive Imprinting and Immune Refocusing in Vaccine Design.” Vaccine. 26, 6189-6199
Nara, P.L., G.J. Tobin, A.R. Chaudhuri, J.D. Trujillo, G. Lin, M. Cho, S.A. Levin, W. Ndifon, and N.S. Wingreen. (2010). “How Can Vaccines Against Influenza and Other Viral Diseases Be Made More Effective?” PLoS Biology. 8, e1000571.
Other Publications:
Presentations:
Textbook Chapters
Lin, G. and G.F. Murphy. (2008). "Case 21: Herpes (Zoster) Folliculitis." Cases in Dermatopathology: Diagnostic Pitfalls in Dermatopathology. Eds. M.P. Hoang, L.M. Duncan, M.C. Mihm, G.F. Murphy, and S.R. Tahan. Knowledge Books and Software: Sandgate, Australia, 183-195.
Lin, G. and M. Hsu. (2009). "Case 13: A 40-year-old Female with Crusting and Patchy Alopecia of the Scalp." Cases in Dermatopathology: Suboptimal Biopsies in Dermatopathology. Eds. M.P. Hoang, L.M. Duncan, M.C. Mihm, G.F. Murphy, and S.R. Tahan. Knowledge Books and Software: Sandgate, Australia, 107-124.
Nara, P.L. and G. Lin. (2009). “Immunodominance, Deceptive Imprinting and Immune Refocusing Technologies.” New Generation Vaccines, 4th Ed. Informa Healthcare: New York, 191-209
Lin, G. and M. Hsu. (2010). "Case 6: Amelanotic Blue Nevus versus Dermatofibroma." Cases in Dermatopathology: Mimicry in Melanocytic Lesions. Eds. M.P. Hoang, L.M. Duncan, M.C. Mihm, G.F. Murphy, and S.R. Tahan. Knowledge Books and Software: Sandgate, Australia, 53-64.
